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Although no causal relationship with REVIA is suspectedphysicians should be aware that treatment with REVIA does not reduce the risk of suicide in these patientssee PRECAUTIONS

Monitor vital signs and observe the patient for signs and symptoms of opioid withdrawalThese may includebut are not limited tonauseavomitingdysphoriayawningsweatingtearingrhinorrheastuffy nosecraving for opioidspoor appetiteabdominal crampssense of fearskin erythemadisrupted sleep patternsfidgetinguneasinesspoor ability to focusmental lapsesmuscle aches or crampspupillary dilationpiloerectionfeverchanges in blood pressurepulse or temperatureanxietydepressionirritabilitybackachebone or joint painstremorssensations of skin crawling or fasciculationsIf signs or symptoms of withdrawal appearthe test is positive and no additional naloxone should be administered.

Safe use of REVIA in ultra rapid opiate detoxification programs has not been establishedsee ADVERSE REACTIONS

REVIA does not interfere with thin-layergas-liquidand high pressure liquid chromatographic methods which may be used for the separation and detection of morphinemethadone or quinine in the urineREVIA may or may not interfere with enzymatic methods for the detection of opioids depending on the specificity of the testPlease consult the test manufacturer for specific details.

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